Skip to main content
  1. Home
  2. Health & Fitness
  3. News

Mitochondria and aging: Why HIIT is the game-changer for fitness and longevity

This study shows HIIT takes the crown when it comes to reversing cellular aging and boosting metabolism

By
man exercising workout ropes HIIT high intensity interval training
Yesenia Mora / Pexels

The mitochondria are considered the ‘powerhouses’ or ‘engines’ of your cells. As Dr. Terry Wahls points out, most chronic diseases involve dysfunctional mitochondria. Poorly functioning mitochondria play a big role in disease risks, a slower metabolism, and the aging process. Researchers have concluded that exercise improves mitochondrial quality and function and stimulates mitochondrial turnover. It’s time to start thinking about these little organelles that have a big impact on our wellness and longevity.

Exercise for your mitochondria

man weightlifting dumbbell row gym bench
Tima Miroshnichenko / Pexels

Additional research also revealed that just 12 weeks of resistance exercise training yielded qualitative and quantitative changes in skeletal muscle mitochondrial respiration. Not only did resistance training increase lean body mass by 4% and quadriceps muscle strength by 15%, but staying committed to those 12 weeks of training also improved the respiratory capacity and functioning of the mitochondria.

Recommended Videos

So, which exercise is superior for improving mitochondrial functioning? Which exercise results in the most dramatic positive cellular changes? Let’s dive into the research.

The study

man and woman lunges in the gym
Julie Larson / Pexels

In a study published in Cell Metabolism, the researchers explored how different types of exercise — resistance training, high-intensity interval training (HIIT), or a mix of both — change muscles and cells at the molecular level in younger and older adults. The researchers focused on how genes and proteins respond to exercise, how exercise impacts the mitochondria, and how these changes affect overall fitness and metabolism.

The study methods

man doing box jump HIIT
Ardit Mbrati / Pexels

For 12 weeks, younger and older adults completed one of three exercise programs: traditional resistance training, HIIT, or a mix of both at a lower intensity. The researchers measured fitness and VO2 peak, insulin sensitivity, muscle mass and strength, mitochondrial health and function, and changes in gene activity and protein levels in muscle.

The results

man exercising working out rope HIIT gym
Cotton Bro / Pexels

Here are the study results:

  • HIIT has the biggest impact in improving aerobic fitness, insulin sensitivity, and mitochondrial function, compared to other workouts. These results were especially noticeable for older adults.
  • HIIT reversed some age-related declines in muscle mitochondria and enhanced the cell’s ability to make new proteins.
  • HIIT enhanced mitochondrial capacity by close to 50% for young adults and nearly 70% in older adults.
  • Resistance training mostly helped build muscle mass and strength, but didn’t have as much of an impact on aerobic fitness or mitochondria. The combined training resulted in smaller and moderate benefits compared to just doing HIIT alone.

Changes at the molecular level

woman doing box jump in a gym
Cotton Bro / Pexels

HIIT caused significant increases in gene activity and protein-building machinery. Most of the benefits from exercise take place after the genes send their signals during the protein-building stage. HIIT improved protein quality and helped reduce damage to muscle proteins, which helps the body build new and efficient mitochondria.

Concluding thoughts

men skipping jumping rope workout HIIT gym
Cotton Bro / Pexels

This study shows that HIIT is one of the most powerful ways to improve muscle health and fitness even in later years. This type of exercise, which involves shorter bursts or intervals of higher-intensity movements, is superior for the mitochondria and helps your body make more and better mitochondria, which can slow age-related decline and boost your energy levels.

Steph Green
Steph Green
Steph Green (Steph Zee) is a singer-songwriter and professional writer with over 12 years of experience in healthcare and… Read Full Bio
Topics
Health & Fitness
Tired of shaky workouts? Meet the MERACH UltraWalk W60 Plus – a walking pad built to last
Animal, Canine, Dog

Finding time to exercise is hard enough. The last thing you need is fitness equipment that feels unstable, sounds like it’s about to fall apart, or struggles to keep up with your pace. Yet that’s exactly what many budget walking pads deliver. Lightweight frames, noisy motors, and limited performance often turn what should be an enjoyable workout into a frustrating experience.

The MERACH UltraWalk W60 Plus aims to change that. Instead of simply offering another compact walking pad, MERACH has built a treadmill-grade under-desk fitness machine designed for long-term reliability, stability, and everyday convenience. Whether you’re walking while working, squeezing in a quick cardio session, or looking to stay active without leaving home, the W60 Plus is engineered to make movement feel effortless.

Read more
Health & Fitness
From wheelchair to walking: The power of mindset, movement, and never giving up
Steph Zee Christmas Secret Music Video Steph Green

I never expected I’d have to learn how to walk again. That journey took me from writing for doctors and magazines to spending thousands of hours researching health and autoimmune disease. When we have excellent health, many of us don’t give it much thought until those sneaky symptoms start to show, and one day it all comes crashing down. Now, our health becomes one of the most important priorities. When we feel good, we can be more productive and chase our dreams. When our health declines and we don’t feel so good, one of our biggest dreams is just to feel better. 

I became a health writer 12 years ago, shortly after graduating with my creative writing degree and getting a diagnosis of the autoimmune bone condition, ankylosing spondylitis. In an effort to improve my health, stay mobile, and help prevent my bones from calcifying and fusing, I spent thousands of hours studying everything from nutrition and naturopathy to conventional medicine and holistic healing. I heard this somewhere, so I can’t take credit, but I like to say I went to “save my ass university”, because pain and illness are some of the biggest motivators.

Read more
Health & Fitness
I tried Magic Mind for a month and here is what happened to my productivity
Furniture, Business Card, Paper

I am proudly an all-brown beverage man. I say it often: I am coffee in the morning, bourbon in the evening, and Pepsi/Coke in between. I know what you’re thinking: What about water? Well, all of those are mostly water. And who wants to drink the same thing they bathe in? That sounds gross. All jokes aside, the coffee addiction is real, and I am not alone. Who thinks they can truly conquer a day without a hard shot of caffeine? I would get it in an IV if it were feasible to do on the subway instead of a cup to go. But that doesn’t have to be the only way you develop your productivity. Instead, you can look to the more natural and healthy methods to maintain and increase your effectiveness. I got my hands on some Magic Mind recently, one of the many different products that claim to elevate brain health, increase mental performance, and, of course, replace the coffee without losing the energy boost. But does it work?

The scientific hoolah

Read more